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007 cr |n|||||||||
008 180519s2018 nju ob 001 0 eng d
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019 _a1078944847
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020 _a9781400890064
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020 _a1400890063
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020 _a9781523124602
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020 _a1523124601
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037 _a9452567
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072 7 _aTEC
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082 0 4 _a620/.5
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049 _aMAIN
100 1 _aZocchi, Giovanni,
_eauthor.
_965143
245 1 0 _aMolecular machines :
_ba materials science approach /
_cGoivanni Zocchi.
264 1 _aPrinceton :
_bPrinceton University Press,
_c2018.
300 _a1 online resource (189 pages)
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
588 0 _aPrint version record.
520 _aMolecular Machines presents a dynamic new approach to the physics of enzymes and DNA from the perspective of materials science. Unified around the concept of molecular deformability--how proteins and DNA stretch, fold, and change shape--this book describes the complex molecules of life from the innovative perspective of materials properties and dynamics, in contrast to structural or purely chemical approaches. It covers a wealth of topics, including nonlinear deformability of enzymes and DNA; the chemo-dynamic cycle of enzymes; supra-molecular constructions with internal stress; nano-rheology and viscoelasticity; and chemical kinetics, Brownian motion, and barrier crossing. Essential reading for researchers in materials science, engineering, and nanotechnology, the book also describes the landmark experiments that have established the materials properties and energy landscape of large biological molecules. Molecular Machines is also ideal for the classroom. It gives graduate students a working knowledge of model building in statistical mechanics, making it an essential resource for tomorrow's experimentalists in this cutting-edge field. In addition, mathematical methods are introduced in the bio-molecular context--for example, DNA conformational transitions are used to illustrate the transfer matrix formalism. The result is a generalized approach to mathematical problem solving that enables students to apply their findings more broadly. Molecular Machines represents the next leap forward in nanoscience, as researchers strive to harness proteins, enzymes, and DNA as veritable machines in medicine, technology, and beyond.
504 _aIncludes bibliographical references (pages 165-172) and index.
505 0 _aCover; Title; Copyright; CONTENTS; Preface; Acknowledgments; Dedication; 1 Brownian Motion; 1.1 Random Walk; 1.2 Polymer as a Simple Random Walk; 1.3 Direct Calculation of p(R); 1.4 The Langevin Approach; 1.5 Correlation Functions; 1.6 Barrier Crossing; 1.7 What is Equilibrium?; 2 Statics of DNA Deformations; 2.1 Introduction; 2.2 DNA Melting; 2.3 Zipper Model; 2.4 Experimental Melting Curves; 2.5 Base Pairing and Base Stacking as Separate Degrees of Freedom; 2.6 Hamiltonian Formulation of the Zipper Model; 2.7 2 × 2Model: Cooperativity from Local Rules; 2.8 Nearest Neighbor Model.
505 8 _a2.9 Connection to Nonlinear Dynamics2.10 Linear and Nonlinear Elasticity of DNA; 2.11 Bending Modulus and Persistence Length; 2.12 Measurements of DNA Elasticity: Long Molecules; 2.13 Measurements of DNA Elasticity: Short Molecules; 2.14 The Euler Instability; 2.15 The DNA Yield Transition; 3 Kinematics of Enzyme Action; 3.1 Introduction; 3.2 Michaelis-Menten Kinetics; 3.3 The Method of the DNA Springs; 3.4 Force and Elastic Energy in the Enzyme-DNA Chimeras; 3.5 Injection of Elastic Energy vs. Activity Modulation; 3.6 Connection to Nonlinear Dynamics: Two Coupled Nonlinear Springs.
505 8 _a4 Dynamics of Enzyme Action4.1 Introduction; 4.2 Enzymes are Viscoelastic; 4.3 Nonlinearity of the Enzyme's Mechanics; 4.4 Timescales; 4.5 Enzymatic Cycle and Viscoelasticity: Motors; 4.6 Internal Dissipation; 4.7 Origin of the Restoring Force g; 4.8 Models Based on Chemical Kinetics (Fisher and Kolomeisky, 1999); 4.9 Different Levels of Microscopic Description; 4.10 Connection to Information Flow; 4.11 Normal Mode Analysis; 4.12 Many States of the Folded Protein: Spectroscopy; 4.13 Interesting Topics in Nonequilibrium Thermodynamics Relating to Enzyme Dynamics; Bibliography.
505 8 _aChapter 1: Brownian MotionChapter 2: Statics of DNA Deformations; Chapter 3: Kinematics of Enzyme Action; Chapter 4: Dynamics of Enzyme Action; Index.
590 _aIEEE
_bIEEE Xplore Princeton University Press eBooks Library
650 0 _aMolecular machinery.
_921018
650 0 _aNanoscience.
_910727
650 0 _aNanotechnology.
_94707
650 6 _aMachinerie mol�eculaire.
_965144
650 6 _aNanosciences.
_965145
650 7 _aTECHNOLOGY & ENGINEERING
_xEngineering (General)
_2bisacsh
_94639
650 7 _aTECHNOLOGY & ENGINEERING
_xReference.
_2bisacsh
_965146
650 7 _aMolecular machinery.
_2fast
_0(OCoLC)fst01983326
_921018
650 7 _aNanoscience.
_2fast
_0(OCoLC)fst01032629
_910727
650 7 _aNanotechnology.
_2fast
_0(OCoLC)fst01032639
_94707
655 0 _aElectronic books.
_93294
655 4 _aElectronic books.
_93294
776 0 8 _iPrint version:
_aZocchi, Giovanni.
_tMolecular Machines : A Materials Science Approach.
_dPrinceton : Princeton University Press, �2018
_z9780691173863
856 4 0 _uhttps://ieeexplore.ieee.org/servlet/opac?bknumber=9452567
938 _aDe Gruyter
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938 _aProQuest Ebook Central
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938 _aEBSCOhost
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938 _aYBP Library Services
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